Both Carboxy-Terminal Tails of α- and β-Tubulin Are Essential, but Either One Will Suffice
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چکیده
منابع مشابه
Both Carboxy-Terminal Tails of α- and β-Tubulin Are Essential, but Either One Will Suffice
contains unique, essential sequence elements, i.e., they Microtubules (MTs) are organized into distinct syshave completely redundant functions. tems essential for cell shape, movement, intracellular Glycylation is known to occur on glutamate residues transport, and division [1]. Electron crystallographic in the C terminus of and -tubulin in cells with axoanalyses [2] provide little information ...
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BACKGROUND Microtubules (MTs) support diverse transport and force generation processes in cells. Both α- and β-tubulin proteins possess carboxy-terminal tail regions (CTTs) that are negatively charged, intrinsically disordered, and project from the MT surface where they interact with motors and other proteins. Although CTTs are presumed to play important roles in MT networks, these roles have n...
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Despite the broadly conserved role of microtubules in chromosome segregation, we have a limited understanding of how molecular features of tubulin proteins contribute to the underlying mechanisms. Here we investigate the negatively charged carboxy-terminal tail domains (CTTs) of α- and β-tubulins, using a series of mutants that alter or ablate CTTs in budding yeast. We find that ablating β-CTT ...
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The kaleidoscopic structures in the electron micrographs above are the bundles of microtubules (axonemes) found in moth and fly sperm tail flagella, shown in cross-section. The axonemes above show the pattern typical of cilia and flagella in insects and other arthropods: nine doublet microtubules surround a central pair of singlet microtubules, and each doublet is associated with a singlet 'acc...
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In this paper we present a model for estimation of the C-terminal tubulin tail (CTT) dynamics in cytoskeletal microtubules of nerve cells. We show that the screened Coulomb interaction between a target CTT and the negatively charged microtubule surface as well as its immediate CTT neighbours results in confinement of the CTT motion within a restricted volume referred to as a thermal cone. Withi...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2002
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(02)00651-6